/ Side by side
MOTS-c vs NAD+
A neutral, side-by-side look at MOTS-c and NAD+: what each one is, its class, half-life, storage, and the public sources behind it. Educational reference only, not medical advice, dosing, or a recommendation to use either compound.
MOTS-c
MOTSc
Full profile →NAD+
Nicotinamide adenine dinucleotide
Full profile →| Attribute | MOTS-c | NAD+ |
|---|---|---|
| Category | GLP-1 / Metabolic | Cognitive / Longevity |
| Half-life | Not well characterized in humans; preclinical estimates short | Intracellular turnover ~1-4 h |
| Common vial | 5, 10 mg | 100, 500 mg |
| Reference | Verified | Verified |
What is MOTS-c?
A 16-amino-acid mitochondrial-derived peptide (encoded within mitochondrial 12S rRNA) that activates AMPK and influences metabolic and mitochondrial pathways, studied as an exercise-mimetic and for metabolic homeostasis.
Sources
- Lee et al., Cell Metab 2015
- Reynolds et al. 2021
What is NAD+?
A ubiquitous redox coenzyme central to cellular energy metabolism and a substrate for enzymes such as sirtuins and PARPs; it is a coenzyme, not a peptide. Studied in aging, metabolic, and neurological research; cellular levels reportedly decline with age.
Sources
- NAD precursors review (PMC8612620)
Educational reference only, compiled from public sources. Not medical advice, diagnosis, treatment, or a dosing recommendation, and not a recommendation to use any compound. Many compounds listed are research materials not approved for human use. Consult a qualified professional.