GLP-1 & Metabolic Peptides
GLP-1 and metabolic compounds are incretin-based molecules and related agents studied in glucose regulation and body-weight research. The class runs from the single GLP-1 receptor agonists to the dual and triple receptor agonists that followed, plus other metabolic peptides. Half-lives here are among the longest in the library, which is why several are studied on a weekly basis in the literature.
10 compounds
Semaglutide
Ozempic · Wegovy · Rybelsus
A GLP-1 receptor agonist, acylated for albumin binding and DPP-4 resistance, studied for glycemic control in type 2 diabetes and for weight management. Its long half-life supports once-weekly administration.
Tirzepatide
Mounjaro · Zepbound
A dual GIP and GLP-1 receptor agonist with a fatty-diacid modification for albumin binding, studied for glycemic control in type 2 diabetes and for weight management. Its half-life supports once-weekly administration.
Retatrutide
Reta · Triple-G · LY3437943
An investigational triple receptor agonist (GIP, GLP-1 and glucagon) conjugated to a fatty-diacid for albumin binding, studied in trials for obesity and metabolic disease. Its half-life supports once-weekly administration.
Cagrilintide
Cagri · NN9838
A long-acting acylated amylin analog engineered to resist aggregation and bind albumin, studied in trials for appetite regulation and weight management, often alongside a GLP-1 agonist. Investigational.
Liraglutide
Saxenda · Victoza
A GLP-1 receptor agonist with a fatty-acid chain enabling self-association and albumin binding, studied for glycemic control in type 2 diabetes and for weight management. Its half-life supports once-daily administration.
Survodutide
BI 456906
An investigational dual glucagon and GLP-1 receptor agonist with high albumin binding, studied in trials for obesity and metabolic-associated liver disease. Its half-life supports once-weekly administration.
AOD-9604
AOD9604 · hGH 176-191
A synthetic peptide corresponding to the C-terminal fragment of human growth hormone (residues 176-191), studied for lipolysis and fat metabolism without the glucose or IGF-1 effects of full-length growth hormone.
Tesamorelin
Egrifta
A stabilized growth-hormone-releasing hormone (GHRH) analog that binds pituitary GHRH receptors to stimulate endogenous growth hormone secretion. FDA-approved (Egrifta) to reduce excess visceral abdominal fat in HIV-associated lipodystrophy.
MOTS-c
MOTSc
A 16-amino-acid mitochondrial-derived peptide (encoded within mitochondrial 12S rRNA) that activates AMPK and influences metabolic and mitochondrial pathways, studied as an exercise-mimetic and for metabolic homeostasis.
Tesofensine
NS2330
An orally active small-molecule triple monoamine reuptake inhibitor (serotonin, noradrenaline, and dopamine), originally developed for neurodegenerative disease and later studied in obesity and metabolic trials. It is a small molecule, not a peptide.
Browse other classes
Educational reference only, compiled from public sources. Not medical advice, diagnosis, treatment, or a dosing recommendation, and not a recommendation to use any compound. Many compounds listed are research materials not approved for human use. Consult a qualified professional.